Si-ROMP Reagents and Cobalt-carbon Magnetic Nanoparticles (Co/C): Generation and Application in Facilitated Protocol for Parallel Synthesis
Pradip K. Maity,a Saqib Faisal,a Quirin M. Kainz,b Oliver Reiser,b and Paul R. Hanson*a
aDepartment of Chemistry, 1251 Wescoe Hall Dr., University of Kansas, Lawrence, KS 66045. NIH Center for Chemical Methodologies and Library Development at the University of Kansas (KU-CMLD), 2034 Becker Drive, Del Shankel Structural Biology Center, Lawrence, KS 66047. bInstitute for Organic Chemistry, University of Regensburg, Universitatsstr. 31, D-93053 Regensburg, Germany.
The process development, scale-up and application of silica-supported ROMP reagents and Nb-tagged Cobalt-carbon (Nb-Co/C) magnetic nanoparticles for the purification-free Parallel synthesis are reported. Utilizing surface-initiated ROM polymerization off SiO2 surface, an array of high load, hybrid Si-immobilized reagents (Si-OBP/Si-OTP) were successfully synthesized as free flowing solid for efficient benzylation and triazolation of nucleophilic species. In addition, utilization of sequestration methods by Nb-tagged Cobalt-graphite (Nb-Co/C) magnetic nanoparticles and Nb-tagged silica (Nb-Si) particles for facilitated intermolecular Mitsunobu Reaction on Hydroxy-pyrrolo thiadiazepin-dioxide scaffolds is also discussed.